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Author: Subject: The Road Goes On Forever ..... dedicated to a Brother

True Peach



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  posted on 1/27/2007 at 12:54 PM
this, my brother Dug, is true.

God sometimes gives us the answer we don't want to hear or we sometimes don't see.

sometimes He says yes.

sometimes He says no, for His reason.

sometimes He says "Wait".

that was real nice, Bobo. That post was a blessing.

 

Zen Peach



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  posted on 1/28/2007 at 08:09 PM
Sunday evening going back to work on Monday brother Bobo bump.

 

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Universal Peach



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  posted on 1/29/2007 at 10:34 PM
A big hug for Cami.....her prayers ARE working... everyday that you live and breath Bobo keeps hope & miracles alive for all of us.

 

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Universal Peach



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  posted on 2/2/2007 at 11:41 AM
Bobo, if it's cocktail Friday today... another shot for that beautiful and very special girl of yours buddy!

 

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True Peach



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  posted on 2/2/2007 at 01:40 PM
You'll like this one, Bobo! My jokes are sooooooo much better than coot's!



Here goes:

A very loud, unattractive, mean woman walked into Wal-Mart with her two kids, yelling obscenities at them all the way through the entrance.

The Wal-Mart Greeter says "Good morning, and welcome to Wal-Mart. Nice children you have there. Are they twins?"

The ugly woman stopped yelling long enough to say, "Hell no they ain't! Oldest one's 9 and the other one's 7. Why the hell would you think they're twins? Are you blind, or just stupid?


"I'm neither blind nor stupid", replied the greeter. "I just couldn't believe you got laid twice."

 

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Universal Peach



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  posted on 2/3/2007 at 10:28 AM
ROFLAO..................................................................

 

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True Peach



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  posted on 2/6/2007 at 09:02 AM
good vibes out to bobo...

...and on another note... here is some possible good news:

http://www.newscientist.com/channel/health/mg19325874.700-cheap-safe-drug-k ills-most-cancers.html
quote:

Cheap, safe drug kills most cancers


New Scientist has received an unprecedented amount of interest in this story from readers. If you would like up-to-date information on any plans for clinical trials of DCA in patients with cancer, or would like to donate towards a fund for such trials, please visit the site set up by the University of Alberta and the Alberta Cancer Board. We will also follow events closely and will report any progress as it happens.

IT SOUNDS almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their "immortality". The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe. It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks.

DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar. Until now it had been assumed that cancer cells used glycolysis because their mitochondria were irreparably damaged. However, Michelakis's experiments prove this is not the case, because DCA reawakened the mitochondria in cancer cells. The cells then withered and died (Cancer Cell, DOI: 10.1016/j.ccr.2006.10.020).

Michelakis suggests that the switch to glycolysis as an energy source occurs when cells in the middle of an abnormal but benign lump don't get enough oxygen for their mitochondria to work properly (see Diagram). In order to survive, they switch off their mitochondria and start producing energy through glycolysis.

Crucially, though, mitochondria do another job in cells: they activate apoptosis, the process by which abnormal cells self-destruct. When cells switch mitochondria off, they become "immortal", outliving other cells in the tumour and so becoming dominant. Once reawakened by DCA, mitochondria reactivate apoptosis and order the abnormal cells to die.
“Once reawakened by DCA, mitochondria order the abnormal cancer cells in a tumour to die”

"The results are intriguing because they point to a critical role that mitochondria play: they impart a unique trait to cancer cells that can be exploited for cancer therapy," says Dario Altieri, director of the University of Massachusetts Cancer Center in Worcester.

The phenomenon might also explain how secondary cancers form. Glycolysis generates lactic acid, which can break down the collagen matrix holding cells together. This means abnormal cells can be released and float to other parts of the body, where they seed new tumours.

DCA can cause pain, numbness and gait disturbances in some patients, but this may be a price worth paying if it turns out to be effective against all cancers. The next step is to run clinical trials of DCA in people with cancer. These may have to be funded by charities, universities and governments: pharmaceutical companies are unlikely to pay because they can't make money on unpatented medicines. The pay-off is that if DCA does work, it will be easy to manufacture and dirt cheap.

Paul Clarke, a cancer cell biologist at the University of Dundee in the UK, says the findings challenge the current assumption that mutations, not metabolism, spark off cancers. "The question is: which comes first?" he says.
From issue 2587 of New Scientist magazine, 20 January 2007, page 13

 

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Zen Peach



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  posted on 2/6/2007 at 09:06 AM
P & L out to Brother Bob...

 

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Universal Peach



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  posted on 2/6/2007 at 11:18 AM
You made me cry Ross. Thank you! Maybe Cami's prayers have been working overtime....

 

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Zen Peach



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  posted on 2/6/2007 at 03:09 PM
Yo Bobo

 

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Sublime Peach



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  posted on 2/7/2007 at 08:05 AM
Where do I begin.... I can't believe I've been a member since 2005 and have never visited the TRGOF thread .. Bobo.... I'm embarrassed and ashamed.... but I'm full of love and hope for you, Bobo as I read through the entire thread and into the new one... I'm so emotional right now as I wipe away the tears...it has been a roller coaster ride with the ups and downs just a struggle of good days versing bad ones...if only we could magically see into our futures and take away all the pain and sadness what a difference it would be , but then again.... I think that is what makes us so strong, is " The " not knowing ... it gives us unbelievable amounts of strength when we think there is nothing left to give...

Bobo reading what your daughter Cami asked you about God..was just so touching, I could barely finish it... May God Bless you and your family.... May he shine a light down on you and bathe in that light.... I wish and hope all the best for you....

You are so loved by all members on the ABB site..I recognize everyone ..... who has been there right from the beginning of this health nightmare, to lend a hand and a word of encouragement along the way... I may be late in coming onto your thread... But I am here as well to send you support of the strongest kind to you... from this day forward Bobo you are in thoughts , prayers everyday....

We will all walk the path you on... I hope I have as much strength and courage and humor as you have...

My love to you and family

rainy

 

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Zen Peach



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  posted on 2/10/2007 at 07:20 PM
Nicely put Rainy ... you pretty much summed up all of our thoughts there

Still thinking of you big guy ... hope your weekend is going well

 

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Zen Peach



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  posted on 2/10/2007 at 09:29 PM
Hey Surfboy, here it is February and I still haven't received your best shows. And don't try using some "illness" as an excuse. Hope all is well brother.

 

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Zen Peach



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  posted on 2/11/2007 at 12:14 AM
quote:
Hey Surfboy, here it is February and I still haven't received your best shows. And don't try using some "illness" as an excuse. Hope all is well brother.


I don't know if you really want his "best" shows. The last "really good" show he sent was an effin Barry Manilow show

 

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Zen Peach



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  posted on 2/11/2007 at 12:15 AM
But he might be starting to get those 2008 Dickey Betts shows

 

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Zen Peach



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  posted on 2/11/2007 at 12:22 AM

 

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It was fun while it lasted




 

Zen Peach



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  posted on 2/11/2007 at 12:25 AM
I think I saw that poster in the post office




P&L as always Brother Bobo

 

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RIP John Ott

 

Zen Peach



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  posted on 2/11/2007 at 08:22 AM
Strange looking people Bobo bump.

 

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Hittin' The Web::Hugh Duty Memorial Giveaway has begun!

RIP Hugh Duty

 

True Peach



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  posted on 2/15/2007 at 04:25 PM
http://www.msnbc.msn.com/id/16975360/
quote:
Lab disaster may lead to new cancer drug
Compound attacks cells that have learned to evade existing treatments

WASHINGTON - Her carefully cultured cells were dead and Katherine Schaefer was annoyed, but just a few minutes later, the researcher realized she had stumbled onto a potential new cancer treatment.

Schaefer and colleagues at the University of Rochester Medical Center in New York believe they have discovered a new way to attack tumors that have learned how to evade existing drugs.

Tests in mice suggest the compound helps break down the cell walls of tumors, almost like destroying a tumor cell’s “skeleton”.
Story continues below &#8595; advertisement

The researchers will test the new compound for safety and hope they can develop it to treat cancers such as colon cancer, esophageal cancer, liver and skin cancers.

“I was using these cancer cells as models of the normal intestine,” Schaefer said in a telephone interview.

Normal human cells are difficult to grow and study in the lab, because they tend to die. But cancer cells live much longer and are harder to kill, so scientists often use them.

Schaefer was looking for drugs to treat the inflammation seen in Crohn’s disease and ulcerative colitis, both of which cause pain and diarrhea.

She was testing a compound called a PPAR-gamma modulator. It would never normally have been thought of as a cancer drug, or in fact a drug of any kind.

“I made a calculation error and used a lot more than I should have. And my cells died,” Schaefer said.

A colleague overheard her complaining. “The co-author on my paper said,’ Did I hear you say you killed some cancer?’ I said ‘Oh’, and took a closer look.”

They ran several tests and found the compound killed ”pretty much every epithelial tumor cell lines we have seen,” Schaefer said. Epithelial cells line organs such as the colon, and also make up skin.

It also killed colon tumors in mice without making the mice sick, they reported in the journal International Cancer Research.

Targets cells
The compound works in much the same way as the taxane drugs, including Taxol, which were originally derived from Pacific yew trees.

“It targets part of the cell cytoskeleton called tubulin,” Schaefer said. Tubulin is used to build microtubules, which in turn make up the cell’s structure.

Destroying it kills the cell, but cancer cells eventually evolve mechanisms to pump out the drugs that do this, a problem called resistance.

“Resistance to anti-tubulin therapies is a huge problem in many cancers. We see this as another way to get to the tubulin,” Schaefer said.

The PPAR-gamma compound does this in a different way from the taxanes, which might mean it could overcome the resistance that tumor cells often develop to chemotherapy.

“Most of the drugs like Taxol affect the ability of tubulin to forms into microtubules. This doesn’t do that -- it causes the tubulin itself to disappear. We do not know why.”

Schaefer’s team plans more safety tests in mice. As the compound is already patented, her team will probably have to design something slightly different to be able to patent it as a new drug.

Taxol, developed by U.S. National Cancer Institute researchers and manufactured by Bristol-Myers Squibb in 1993, had annual sales of $1.6 billion at its peak in 2000.

 

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There's no way to rule innocent men. The only power government has is the power to crack down on criminals. When there aren't enough criminals, one makes them. One declares so many things to be a crime that it becomes impossible for men to live without br

 

Zen Peach



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  posted on 2/17/2007 at 07:55 PM
Pre-President's Day Bobo bump.

 

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Sublime Peach



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  posted on 2/19/2007 at 07:42 PM
A love ^ for Bobo .....

 

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Universal Peach



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  posted on 2/22/2007 at 08:37 AM
Hey Bobo! Love & prayers to you and yours.....

 

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Zen Peach



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  posted on 2/22/2007 at 03:19 PM
I typically don't do this but today I would ask you for your prayers and good vibes. I have not been feeling well and my Doctor is concerned that the Chemo is not working. So, he is bumping up my tests - I have both a Bone (to see how the Cancer in my hip is "doing") Scan and a CT-Scan (to check on my lymph nodes). I'll get the results on Monday.

Throughout this whole thing, I have tried not to worry, but I'd be lying if I said I wasn't scared. This community's positive vibes mean a great deal to me so thanks in advance.

 

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"Without going out of my door, I can know all things on Earth. Without looking out of my window, I can know all things in Heaven. The farther one travels, the less one really knows."

 

Zen Peach



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  posted on 2/22/2007 at 03:22 PM
Love and positive vibes sent your way, Bob.

If our vibes mean alot to you, you mean even more to us.

Please let us know your results if you want to share.

 

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Sublime Peach



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  posted on 2/22/2007 at 03:24 PM
Much love, prayers and positively good vibes headed your way Bobo.

We love you and we are all here if you need us....((bobo))

Karen, Lynn and family

 

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